2025-10-23·9 min read·Maternal Health

Neonatal Complications for the NCLEX: RDS, NEC, and Hyperbilirubinemia

Common neonatal complications including respiratory distress syndrome, NEC, and jaundice management.

Respiratory Distress Syndrome (RDS)

  • Caused by surfactant deficiency - primarily affects preterm infants <35 weeks
  • Signs: tachypnea, nasal flaring, intercostal retractions, grunting, cyanosis
  • Treatment: surfactant replacement therapy (via ET tube), CPAP or mechanical ventilation, oxygen
  • Prevention: antenatal corticosteroids (betamethasone) when preterm delivery is anticipated

Necrotizing Enterocolitis (NEC)

  • Inflammation and necrosis of intestinal tissue - most common GI emergency in neonates
  • Signs: abdominal distension, bloody stools, feeding intolerance, bilious emesis
  • X-ray: pneumatosis intestinalis (air in bowel wall)
  • Treatment: NPO, NG decompression, IV antibiotics, TPN. Surgery if perforation
  • Prevention: breast milk (protective factor)

Hyperbilirubinemia (Jaundice)

  • Physiologic: Appears after 24 hours, peaks at 3-5 days. Common, usually benign
  • Pathologic: Appears within first 24 hours - indicates hemolytic process. Requires immediate evaluation
  • Treatment: phototherapy (blue light), adequate hydration, monitor bilirubin levels
  • Complication: kernicterus (bilirubin deposits in brain) - neurological damage

Review Maternal-Newborn cheat sheet and Newborn Assessment deep dive.