Isolation Precautions

Standard, contact, droplet, and airborne precautions with PPE requirements and disease-specific guidelines.

Standard Precautions (Apply to ALL Patients)

  • Hand hygiene before and after every patient contact
  • Gloves when touching blood, body fluids, mucous membranes, non-intact skin
  • Gown if clothing may become soiled
  • Mask + eye protection if splash/spray is anticipated
  • Safe injection practices (single-use needles, no multi-dose vial contamination)
  • Respiratory hygiene/cough etiquette
  • Safe handling of contaminated equipment and linens

Transmission-Based Precautions

TypeContactDropletAirborne
Transmission Direct or indirect contact with patient or contaminated surfaces Large respiratory droplets (> 5 microns) travel ≤ 3 feet Small airborne particles (≤ 5 microns) remain suspended in air
Room Private room preferred; cohort if same organism Private room; door may remain open Airborne Infection Isolation Room (AIIR) — negative pressure, 6–12 air exchanges/hr, door must remain closed
PPE Required Gloves + Gown (upon room entry) Surgical mask (within 3–6 feet) N95 respirator or PAPR (must be fit-tested)
Patient Transport Limit transport; cover infected area Patient wears surgical mask during transport Patient wears surgical mask during transport; notify receiving department
Equipment Dedicated equipment (stethoscope, BP cuff); disinfect between patients Routine cleaning Routine cleaning

Diseases by Precaution Type

Contact Precautions

Remember: "MRSA Cdiff VRE"

  • MRSA (Methicillin-Resistant Staphylococcus aureus)
  • C. difficile (use soap and water, not alcohol-based sanitizer)
  • VRE (Vancomycin-Resistant Enterococcus)
  • Scabies
  • Lice (pediculosis)
  • Herpes simplex (disseminated or primary severe)
  • Impetigo
  • Wound infections with heavy drainage
  • Rotavirus
  • RSV (Respiratory Syncytial Virus) — contact + droplet

Droplet Precautions

Remember: "SPIDERMAN" — Sepsis, Pertussis, Influenza, Diphtheria (pharyngeal), Epiglottitis, Rubella, Meningitis (bacterial), Adenovirus, Norovirus (also contact), Mumps

  • Influenza
  • Pertussis (whooping cough)
  • Bacterial meningitis (Neisseria, H. influenzae)
  • Mumps
  • Rubella (German measles)
  • Diphtheria (pharyngeal)
  • Streptococcal pharyngitis
  • Pneumonia (Mycoplasma, Group A Strep)
  • Epiglottitis

Airborne Precautions

Remember: "MTV" — Measles, Tuberculosis, Varicella (chickenpox/disseminated zoster)

  • Measles (rubeola)
  • Tuberculosis (pulmonary or laryngeal)
  • Varicella (chickenpox)
  • Disseminated herpes zoster (shingles)
  • SARS / COVID-19 (during aerosol-generating procedures)
  • Smallpox

Special Considerations

SituationAction
C. difficile hand hygieneSoap and water ONLY (alcohol does not kill spores)
TB suspectedPlace in AIIR immediately; initiate airborne precautions before confirmation
N95 fittingAnnual fit-testing required; facial hair prevents proper seal
Chickenpox exposure in non-immune HCWFurlough days 10–21 post-exposure
Pregnant nurse assignmentsAvoid caring for patients with CMV, varicella (if non-immune), herpes zoster, rubella
Immunocompromised patientProtective (reverse) isolation: private room, positive pressure, mask for visitors, no fresh flowers/fruits

PPE Donning and Doffing Order

  • Donning (putting on): Gown → Mask/Respirator → Goggles/Face shield → Gloves
  • Doffing (removing): Gloves → Goggles/Face shield → Gown → Mask/Respirator
  • Perform hand hygiene after each piece is removed and after all PPE is off